The James Petigru Boyce Chapel is a historic church building at 1306 Hampton Street in Columbia, South Carolina. It is a Greek Revival building built in 1859. A convention met here on December 17, 1860, whose delegates voted unanimously for South Carolina to secede from the United States, leading to the American Civil War. It was designated a National Historic Landmark as First Baptist Church, the role it played at the time. The building is part of the facilities complex of the First Baptist Church, Columbia- a Southern Baptist megachurch.